The aim of the Position Paper “Transformational Governance: a responsible conduct driver for a more ethical, prosperous and sustainable business” is to take a snapshot of how Italian companies participating in the UN Global Compact are interpreting and implementing the integration of sustainability within their governance mechanisms. This is a fundamental and unavoidable dimension allowing companies to promote sustainable business, from a strategic, cultural and operational point of view, starting from the top and managerial levels, and permeating all the organisation’s levels. The Paper was produced with the support of 54 companies and showcases 20 business cases on the topic. The Paper was officially launched on July 17, 2024, in collaboration with the Permanent Mission of Italy to the UN and as part of a side-event of the High-Level Political Forum in New York.